QUESTION

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Several analogues of a drug are to be prepared for a QSAR study, which will consider the effect of various aromatic substituents on biological activity. You are asked whether the substituents $\left(\mathrm{SO}_{2} \mathrm{NH}_{2}\right.$, $\mathrm{CF}_{3}, \mathrm{CN}, \mathrm{CH}_{3} \mathrm{SO}_{2}, \mathrm{SF}_{3}, \mathrm{CONH}_{2}, \mathrm{OCF}_{3}, \mathrm{CO}_{2} \mathrm{H}$, $\mathrm{Br}, \mathrm{I})$ are relevant to the study. What are your thoughts?

Public Answer

62HHQ4 The First Answerer